Impact of Orange Juice Consumption on Glucose Homeostasis and Antioxidative Status in Healthy Subjects
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 26
- 试验地点
- 2
- 主要终点
- changes in daylong glycaemia between pre and post intervention periods
研究概览
简要总结
Aim of the study is to investigate the impact of orange juice consumption (with meals or between meals) as well as sugar sweetened beverage (SSB) consumption (between meals) on glucose homeostasis and antioxidative status.
详细描述
Duration of the study is 3x three weeks including one wash-out week each followed by two weeks of juice/SSB consumption under free living conditions.
During wash-out weeks consumption of orange juice or citrus fruits is restricted.
During intervention weeks, participants are asked to eat three regular meals per day without snacking. Intervention weeks are (i) orange juice consumption with meals (ii) orange juice consumption between meals and (iii) SSB consumption between meals. Daily energy intake with orange juice/SSB is 20% of individual energy requirement. Additional caloric beverages (SSB, juice, coffee with sugar/milk, alcohol) are not allowed. At the beginning and the end of each intervention phase insulin sensitivity and antioxidative status are assessed.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 45 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- •regular use of medication,
- •chronic disease,
- •vegan/vegetarian diet,
- •fructose intolerance,
- •irregular eating behaviour (less then 3 meals/day)
结局指标
主要结局
changes in daylong glycaemia between pre and post intervention periods
时间窗: two weeks
measured via continuous glucose monitoring \[mg/dL\]
次要结局
- changes in insulin sensitivity between pre and post intervention periods(two weeks)
- changes in uric acid between pre and post intervention periods(two weeks)
- changes in antioxidative status between pre and post intervention periods(two weeks)