Gender Heterogeneity in the Influencing Factors for Cerebral Microbleeds in Acute Ischemic Stroke Patients

Completed

• Conditions: Acute Ischemic Stroke
• Interventions: Other: cerebral microbleeds

• Registration Number: NCT05882123
• Lead Sponsor: Xin Guo

Brief Summary

The investigators continuously collected data from 482 AIS inpatients at the Neurology Department of Hebei General Hospital. Both demographic and clinical data were collected from the study subjects. Different head magnetic resonance imaging sequences were used to assess the subjects' CMBs, white matter lesions, and old lacunar infarcts (LI). Various statistical methods, including the t-test, χ2 test, and logistic regression, were used to analyze the gender heterogeneity of the influencing factors for CMBs in AIS patients.

Detailed Description

Not available

Study Timeline

• Study Start: 2014-01
• Primary Completion: 2015-12
• Study Completion: 2015-12
• Status Verified: 2023-05
• Study First Submitted: 2023-05-11
• Study First Submitted QC: 2023-05-21
• Last Update Submitted: 2023-05-21
• Study First Posted: 2023-05-31
• Last Update Posted: 2023-05-31

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 482

Inclusion Criteria

• Aged 18 years and older
• Must meet the diagnostic criteria for AIS as presented in the Chinese Guidelines for Diagnosis and Treatment of Acute Ischemic Stroke 2014
• Must be in good physical condition and have the ability to cooperate with MRI examinations
• Must have underwent SWI

Exclusion Criteria

• MRI contraindications present, such as cardiac pacemaker, cardiac stents, or metal implants
• Head MRI or carotid artery ultrasound suggests the presence of severe stenosis or occlusion in the intracranial or extracranial segments of the cerebral arteries
• Severe comorbid diseases, such as cardiac, pulmonary, hepatic, and renal insufficiencies

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
male; female	cerebral microbleeds	-
without CMBs; with CMBs	cerebral microbleeds	-

Primary Outcome Measures

Name	Time	Method
Comparison of CMB-related characteristics between the male and female AIS patients	from January 2014 to December 2015	Differences in CMB-related characteristics between the male and female AIS patients
Predictive factor analysis for CMBs in female AIS patients	from January 2014 to December 2015	CMB-related factors in female AIS patients
Comparison of clinical data between AIS patients in CMB and non-CMB groups	from January 2014 to December 2015	Differences in general information between AIS patients in CMB and non-CMB groups
Comparison of clinical data between male and female AIS patients	from January 2014 to December 2015	Differences in general informationbetween male and female AIS patients
Predictive factor analysis for CMBs in male AIS patients	from January 2014 to December 2015	CMB-related factors in male AIS patients