Acute Coronary Disease (ACS)- Strain

Completed

• Conditions: Cardiac and Non Cardiac Thoracal Disorder
• Interventions: Other: retrospective echographic myocardial strain analysis refering to acute coronary syndrome

• Registration Number: NCT02357641
• Lead Sponsor: RWTH Aachen University

Brief Summary

Examination of probable distinction between cardiac or non- cardiac thoracal disorder via echocardiographic myocardial strain analysis

Detailed Description

Patients with cardiac disorder have to undergo time- consuming and expensive examinations such as laboratory of cardiac biomarkers or ischemic diagnostic. To save time and money in this observational registry the probable distinction between cardiac and non- cardiac disorder in patients with vague thoracal disorder and the probability for coronary artery disease (determined via Grace Score) is examined via echographic myocardial strain analysis in 300 patients retrospectively to establish a cut off value corresponding to acute coronary disease also to prevent coronary angiography. Therefore patients undergo echography routinely with consecutive evaluation of systolic, diastolic and strain analysis to elevate exact statements with reference to deformation of the myocard and its velocity. Several study have shown that these strain parameters (circumferential and radial strain) enable vitality and ischemic diagnosis and therefore could be eligible for this purpose.

Study Timeline

• Study Start: 2013-11
• Primary Completion: 2015-01
• Study Completion: 2015-01
• Study First Submitted: 2015-01-26
• Status Verified: 2015-02
• Study First Submitted QC: 2015-02-03
• Last Update Submitted: 2015-02-03
• Study First Posted: 2015-02-06
• Last Update Posted: 2015-02-06

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 300

Inclusion Criteria

• thoracal cardiac or non cardiac disorder
• signed informed consent

Exclusion Criteria

• glomerular filtration rate (GFR) < 60 ml/min
• angina pectoris
• acute myocardial infarction within 3 months prior inclusion
• pregnancy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with thoracal disorder	retrospective echographic myocardial strain analysis refering to acute coronary syndrome	300 patients with thoracal disorder, cardiac or non- cardiac, are enrolled prospectively to undergo routinely examinations such as clinical and hemodynamic chemistry as well as echocardiography for strain analysis refering to myocardial deformation. Especially analysis of strain data (circumferential and radial), regional and global left and right ventricular wall movement data and diastolic parameters will be analysed retrospectively to investigate a probable cut off value corresponding to acute coronary disease or non cardiac disorder (Intervention: retrospective echographic myocardial strain analysis refering to acute coronary syndrome).

Primary Outcome Measures

Name	Time	Method
Determination of cut off value of circumferential and radial myocardial echographic strain data corresponding to acute coronary disease	1 year

Trial Locations

Locations (1)

Department of Cardiology, RWTH Aachen University Hospital; 🇩🇪 Aachen, North Rhine Westphalia, Germany