Effects of Volatile and Intravenous Anesthetics on Pupillary Function

• Conditions: Pupillary Functions, Abnormal
• Interventions: Other: sevoflurane; Other: propofol

• Registration Number: NCT03987529
• Lead Sponsor: Seoul National University Hospital

Brief Summary

To compare of effects of volatile and intravenous anesthetics on pupillary function during general anesthesia in children

Detailed Description

The investigator will measure the pupillary function with pupillometry during general anesthesia with volatile or intravenous anesthetics in children.

Study Timeline

• Study First Submitted: 2019-06-13
• Study First Submitted QC: 2019-06-13
• Study First Posted: 2019-06-17
• Status Verified: 2020-08
• Study Start: 2020-08-12
• Last Update Submitted: 2020-08-12
• Last Update Posted: 2020-08-17
• Primary Completion: 2021-02-28
• Study Completion: 2021-02-28

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 22

Inclusion Criteria

• Pediatric patients undergoing general anesthesia

Exclusion Criteria

• If injection of any agents that can change pupil size or index
• Any severe side effects, adverse drug reaction

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Sevoflurane+Remifentanil	sevoflurane	Using inhalent agent(Sevoflurane), continuous infusion of Remifentanil
Propofol+Remifentanil	propofol	Using continuous infusion of Propofol and Remifentanil

Primary Outcome Measures

Name	Time	Method
NPi	1hour afer skin incision	Neurological Pupil index

Secondary Outcome Measures

Name	Time	Method
CV	1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation	Constriction Velocity
DV	1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation	Dilation Velocity
NPi	1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation	Neurological Pupil index
%CH	1. Stage of loss of consciousness after induction with bolus propofol 2. Before and after tracheal intubation 3. Skin incision 4. 1hour afer skin incision 5. Just before extubation	% change of pupil size

Trial Locations

Locations (1)

Seoul National University Hospital; 🇰🇷 Seoul, Korea, Republic of