The Improvement of Intraoperative Neuromonitoring of Recurrent Laryngeal Nerve During Thyroid Surgery
Overview
- Phase
- Not Applicable
- Intervention
- sugammadex
- Conditions
- Thyroid Intra-Operative Injury
- Sponsor
- Kaohsiung Medical University Chung-Ho Memorial Hospital
- Enrollment
- 60
- Locations
- 1
- Primary Endpoint
- sugammadex 2 mg/kg allows effective and rapid restoration of neuromuscular function suppressed by rocuronium
- Status
- Completed
- Last Updated
- 4 years ago
Overview
Brief Summary
Objectives: The use of neuromuscular blocking agent may interfere with the function of intraoperative neuromonitoring (IONM) in thyroid surgery.
Detailed Description
An enhanced neuromuscular-blockade (NMB) recovery protocol was investigated in a clinically applied during thyroid neural monitoring surgery. In as subsequent clinical application study, 60 patients who underwent thyroidectomy with IONM followed an enhanced NMB recovery protocol- rocuronium 0.6 mg/kg at anesthesia induction and sugammadex 2 mg/kg at operation start. Train-of-four (TOF) ratio was used for continuous quantitative monitoring of neuromuscular transmission.
Investigators
I-Cheng Lu
Doctor
Kaohsiung Medical University Chung-Ho Memorial Hospital
Eligibility Criteria
Inclusion Criteria
- •patients undergoing intraoperative neuromonitoring of recurrent laryngeal nerve during thyroidectomy
Exclusion Criteria
- •Patients with a history of significant cardiac, pulmonary, hepatic, or renal disease, body mass index \<18.5 or \>35, chronic drug or alcohol abuse
Arms & Interventions
Enhanced recovery
rocuronium 2 effective dose at anesthesia induction sugammadex after skin incision and before extubation (total 2 mg/kg iv)
Intervention: sugammadex
Outcomes
Primary Outcomes
sugammadex 2 mg/kg allows effective and rapid restoration of neuromuscular function suppressed by rocuronium
Time Frame: 1 month each case
Electromyography signal to assess the quality of neuromonitoring