Electroencephalogram during increasing and decreasing desflurane concentration - Electroencephalogram change by desflurane

Conditions: Surgical patients scheduled for elective surgery under general anaesthesia. Otherwise in stable medical condition (ASA status less than 3)
MedDRA version: 12.0Level: LLTClassification code 10023693Term: Laparoscopy
MedDRA version: 12.0Level: LLTClassification code 10023696Term: Laparotomy
MedDRA version: 12.0Level: LLTClassification code 10023697Term: Laparotomy & drainage
MedDRA version: 12.0Level: LLTClassification code 10051777Term: Staging laparotomy
MedDRA version: 12.0Level: LLTClassification code 10053361Term: Explorative laparotomy
MedDRA version: 12.0Level: LLTClassification code 10069054Term: Pelvic laparoscopy

Registration Number: EUCTR2009-014620-36-FI

Lead Sponsor: Tampere University Hospital

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: ot Recruiting

Sex: All

Target Recruitment: 30

Inclusion Criteria

Enrollment criteria of the patients are:
- obtained written informed consent to assign the study.
- age range from 18 to 70 years old.
- scheduled for abdominal surgical procedures planned to last for more than 90 minutes, and requiring general anaesthesia with tracheal intubations and epidural analgesia for postoperative pain treatment.
- American Society of Anesthesiologists Classification of Physical Status 3 or less.

Are the trial subjects under 18? no
Number of subjects for this age range:
F.1.2 Adults (18-64 years) yes
F.1.2.1 Number of subjects for this age range
F.1.3 Elderly (>=65 years) yes
F.1.3.1 Number of subjects for this age range

Exclusion Criteria

Exclusion criteria of the patients are:
- pregnancy.
- obesity defined as BMI > 30.
- any significant cardiovascular, respiratory or neurological diseases.
- any significant disorders of the autonomic and central nervous systems.
- receiving medication known to affect the central nervous system activity (receiving medication for hypertension is not exclusion criteria).
- overuse of alcohol, use of illicit drugs.
- family history of malignant hyperthermia.
- clinical history of anaphylactic reaction against inhaled anaesthetics.
- disablity to communicate with Finnish language.

Study & Design

Study Type: Interventional clinical trial of medicinal product

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Main Objective: In the present study we will obtain the EEG from relatively healthy (ASA-PS less than 3) patients undergoing desflurane anaesthesia. We will increase and decrease the desflurane concentrations and correlate the behaviour of raw EEG. ;Secondary Objective: To commercially available indices (BIS and Entropy) and to the concentration of desflurane. ;Primary end point(s): Primary endpoint is the behaviour of EEG as a function of desflurane concentration.<br>

Secondary Outcome Measures