Optical Coherence Tomography Angiography (OCT-A) and Central Serous Chorioretinopathy (CSC)

Completed

• Conditions: Central Serous Chorioretinopathy
• Interventions: Device: Optical Coherence Tomography Angiography (OCT-A)

• Registration Number: NCT03950089
• Lead Sponsor: Hospices Civils de Lyon

Brief Summary

Optical Coherence Tomography Angiography (OCT-A) is a noninvasive imaging technique that allows one to see blood vessels in the retina. The investigating team used this approach in patients with acute, recurrent and persistent subtypes of Central Serous Chorioretinopathy (CSC) to check for possible Choriocapillaris hypoperfusion. The presence or absence of these microvascular changes was explored in both eyes of the patients and compared to a control group of healthy volunteers. The possibility of a correlation between Choriocapillaris flow deficits, age and spontaneous resolution of serous retinal detachment was also evaluated. This study was conducted in an effort to improve one's understanding of this disease and other pachychoroid disorders.

Detailed Description

Not available

Study Timeline

• Study Start: 2016-07-01
• Primary Completion: 2017-09-30
• Study Completion: 2017-09-30
• Status Verified: 2019-05
• Study First Submitted: 2019-05-09
• Study First Submitted QC: 2019-05-10
• Last Update Submitted: 2019-05-10
• Study First Posted: 2019-05-15
• Last Update Posted: 2019-05-15

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 120

Inclusion Criteria

• Patients with acute, recurrent or persistent forms of central serous chorioretinopathy

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Exclusion Criteria

• Patients with chronic central serous chorioretinopathy were not eligible for inclusion

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients with Central Serous Chorioretinopathy	Optical Coherence Tomography Angiography (OCT-A)	-
Healthy patients	Optical Coherence Tomography Angiography (OCT-A)	-

Primary Outcome Measures

Name	Time	Method
Total number average individual area of flow signal voids	2 months	3x3 Optical Coherence Tomography Angiography (OCT-A) images on choriocapillaris slab were exported from the Angioplex software and then imported into the open-source Fiji software. Each image was binarized in black and white pixels. Thresholded areas greater than or equal to 1 white pixel were considered as flow signal voids
Total area of flow signal voids	2 months	3x3 Optical Coherence Tomography Angiography (OCT-A) images on choriocapillaris slab were exported from the Angioplex software and then imported into the open-source Fiji software. Each image was binarized in black and white pixels. Thresholded areas greater than or equal to 1 white pixel were considered as flow signal voids