Effect of flavanones of orange juice absorption on blood lipid profile

Not Applicable

• Conditions: Body weight; healthy individuals; 28381

• Registration Number: RBR-8pgbfpv
• Lead Sponsor: Faculdade de Ciências Farmacêuticas da Universidade de São Paulo

Brief Summary

As expected, a heterogeneity on biological response was observed after consumption of orage juice, but within the reference values for each biochemical parameter evaluated. Significantly decrease (significance value lower than 0.05) in the percentage of body fat (from 35 to 31 percent) and low density lipoprotein (from 119 to 97 milligram per hundred mililiter) were observed. As a preliminary conclusion, the intake of orange juice during 60 days positively influence the parameters evaluated, contributing to a health effect.

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2022-08-25
• Last Update Posted: 29 May 2023
• Study Completion: 2024-01-30

Recruitment & Eligibility

• Status: Recruitment completed
• Sex: Not specified
• Target Recruitment: Not specified

Inclusion Criteria

Healthy individuals; aged 19 to 40 years; with nutritional diagnosis of eutrophy and / or overweight (BMI = 19.0-24.99 Kg / m2 and 25 to 29.9 Kg / m2). Do not have a history of cardiovascular, gastrointestinal, hepatic or renal dysfunction; not be an alcoholic (daily alcohol consumption); not be diabetic; not have any type of infection; not using vitamin and mineral supplements, in addition to antibiotics, antacids or medication for diarrhea or constipation; not be a smoker; not having an aversion to orange juice; women volunteer cannot be pregnant, breastfeeding or undergoing hormone replacement therapy for menopause.

Exclusion Criteria

Present a history of cardiovascular, gastrointestinal, hepatic or renal dysfunction; being an alcoholic (daily alcohol consumption); being diabetic; presenting any type of infection; be using vitamin and mineral supplements, in addition to antibiotics, antacids or medications for diarrhea or constipation; being a smoker; aversion to orange juice; pregnant women, lactating women or menopausal hormone replacement therapy.

Study & Design

• Study Type: Intervention
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
An improvement on biochemical blood parameters was expected after orange juice consumption, analysed by classical biochemical analysis. The individuals responded differently to the consumption of orange juice. After 60 days of ingestion of orange juice, a reduction in the percentage of body fat was observed, and through biochemical tests, a reduction in liver enzymes glutamic oxalacetic transaminase (TGO) and glutamic piruvic transaminase (TGP) and triglycerides was observed.<br>Evaluated parameters: glycemy, insulin, total cholesterol, high density lipoprotein, low density lipoprotein, TGO, TGP, blood pressure, body weight, body fat percentage.

Secondary Outcome Measures

Name	Time	Method
A decrease in some pro-inflammatory cytokines were expected after orange juice consumption, analysed by flow cytometry. It was possible to observed a significant reduction (p lower than 0.05) of some pro-inflammatory cytokines, IL-2, IL-6, ICAM-1, VCAM-1. Cytokines evaluated: Interleukines (IL) IL-1, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12, IL-17, interferon-? (IFN-?), tumor necrosis factor (TNF-a), C-reactive protein (PCR), adiponectin, monocyte chemoattractant protein-1 (MCP-1), Intercelulatr adhesion molecule-1 (ICAM-1) and vascular cell adhesion-1 (VCAM-1)