Neurohumoral Control of Intestinal Electrical and Mechanical Activity
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Morbid Obesity
- Sponsor
- University of California, Davis
- Enrollment
- 45
- Locations
- 2
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
A collaborative research project with Dr. Kathleen Keef (Department of Physiology, University of Nevada School of Medicine, Reno, Nevada) studying the role of putative neurotransmitters in human intestine.
Detailed Description
Segments of intestine from patients undergoing elective gastric bypass for morbid obesity or resections for non-obstructive neoplasms at the UC Davis Medical Center will be used. Samples will be taken from tissue normally removed and sent to Pathology or discarded. Full thickness segments of intestine (10 mm x 1 mm) will be prepared for recording either intracellular electrical activity or mechanical contraction. The effects of putative non-adrenergic, non-cholinergic neurotransmitters (e.g., nitric oxide) will be studied. The source of the tissue will not be identified either directly or indirectly through identifiers associated with the measured responses.
Investigators
Eligibility Criteria
Inclusion Criteria
- •All patients having elective bowel resection
Exclusion Criteria
- •Entire resected segment required for pathology
- •Ischemic/necrotic disease
Outcomes
Primary Outcomes
Not specified