Neurohumoral Control of Intestinal Electrical and Mechanical Activity

Completed

• Conditions: Morbid Obesity

• Registration Number: NCT00852553
• Lead Sponsor: University of California, Davis

Brief Summary

A collaborative research project with Dr. Kathleen Keef (Department of Physiology, University of Nevada School of Medicine, Reno, Nevada) studying the role of putative neurotransmitters in human intestine.

Detailed Description

Segments of intestine from patients undergoing elective gastric bypass for morbid obesity or resections for non-obstructive neoplasms at the UC Davis Medical Center will be used. Samples will be taken from tissue normally removed and sent to Pathology or discarded. Full thickness segments of intestine (10 mm x 1 mm) will be prepared for recording either intracellular electrical activity or mechanical contraction. The effects of putative non-adrenergic, non-cholinergic neurotransmitters (e.g., nitric oxide) will be studied. The source of the tissue will not be identified either directly or indirectly through identifiers associated with the measured responses.

Study Timeline

• Study Start: 2003-02
• Study First Submitted: 2009-02-26
• Study First Submitted QC: 2009-02-26
• Study First Posted: 2009-02-27
• Primary Completion: 2012-02
• Study Completion: 2012-02
• Status Verified: 2017-05
• Last Update Submitted: 2017-05-24
• Last Update Posted: 2017-05-30

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 45

Inclusion Criteria

• All patients having elective bowel resection

Exclusion Criteria

• Entire resected segment required for pathology
• Ischemic/necrotic disease

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Trial Locations

Locations (2)

University of California, Davis Medical Center; 🇺🇸 Sacramento, California, United States

University of Nevada School of Medicine; 🇺🇸 Reno, Nevada, United States