Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men

Not Applicable

Completed

• Conditions: Weight-Lifting Exercise Program
• Interventions: Behavioral: Lower-repetition, heavier-load; Behavioral: Higher-repetition, lighter-load

• Registration Number: NCT02842593
• Lead Sponsor: McMaster University

Brief Summary

This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.

Detailed Description

Not available

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2014-09
• Study First Submitted: 2016-07-15
• Study First Submitted QC: 2016-07-20
• Study First Posted: 2016-07-25
• Primary Completion: 2016-08
• Study Completion: 2016-08
• Status Verified: 2017-01
• Last Update Submitted: 2017-01-13
• Last Update Posted: 2017-01-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Male
• Target Recruitment: 60

Inclusion Criteria

• Male
• Aged 18-30 years old
• Non-obese (Body mass index less than 30 kg/m2)
• Non-smoker
• Healthy based on questionnaire responses
• Resistance trained (Resistance training > 2 times per week for 2 years, minimum 1 lower body exercise session per week)

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Exclusion Criteria

• Allergies to milk proteins (whey or casein)
• Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
• Arthritic conditions
• Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded
• A history of neuromuscular problems
• Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

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Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Resistance exercise training	Lower-repetition, heavier-load	Whole-body resistance exercise training 4x/week for 12 weeks. Either 'lower-repetition, heavier-load' or 'higher-repetition, lighter-load' intervention.
Resistance exercise training	Higher-repetition, lighter-load	Whole-body resistance exercise training 4x/week for 12 weeks. Either 'lower-repetition, heavier-load' or 'higher-repetition, lighter-load' intervention.

Primary Outcome Measures

Name	Time	Method
Carotid-femoral pulse wave velocity	12 weeks post exercise training	Assessed using applanation tonometry

Secondary Outcome Measures

Name	Time	Method
Left ventricular mass	12 weeks post exercise training	Assessed using standard echocardiography
Common carotid artery distensibility	12 weeks post exercise training	Assessed using vascular ultrasound

Trial Locations

Locations (1)

McMaster University; 🇨🇦 Hamilton, Ontario, Canada