The effect of exercise induced extra-thoracic airway obstruction on end expiratory lung volume in children.

Withdrawn

• Conditions: Exercise induced airway obstruction; Exercise induced asthma; 10046304

• Registration Number: NL-OMON32324
• Lead Sponsor: Medisch Spectrum Twente

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Withdrawn
• Sex: Not specified
• Target Recruitment: 0

Inclusion Criteria

Inclusion criteria (asthmatic subjects)
- Clinical history of allergic rhinitis and/or allergic asthma.
- Age between 12 and 17 years.
- Ability to perform reproducible lung function tests, i.e. coefficient of the predicted
value variation in 3 of 5 consecutive measurements < 5%.
- Maximal FEV1 greater than 70% of predicted value.
- Clinically stable period at least 3 weeks before the study period. ;Inclusion criteria (healthy subjects)
- No currently reported illnesses.
- Age between 12 and 17 years.
- Ability to perform reproducible lung function tests, i.e. coefficient of the predicted
value variation in 3 of 5 consecutive measurements < 5%.
- Maximal FEV1 greater than 70% of predicted value.
- Clinically stable period at least 3 weeks before the study period.

Exclusion Criteria

Exclusion criteria (asthmatic subjects)
- Use of intranasal or systemic corticosteroids in the last 4 weeks prior to the study.
- Use of antihistamines, cromoglycates, anticholinergics in two weeks prior to the study.
- Use of long acting bronchodilators 24 hours before testing.
- Use of short acting bronchodilators 8 hours before testing.
- Other pulmonary or cardiac disorder.
- Deviation of the FEV1 of more than 12 % from baseline spirometry and the FEV1 before subsequent exercise provocation challenges.
- Signs of gastro-esophageal reflux. ;Exclusion criteria (healthy subjects)
- Reported Illness in the past.
- Exhaled NO of more than 20 ppb
- Signs of gastro-esophageal reflux.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>The study endpoint will be the end of the exercise provocation test, where<br /><br>change in MIF50 will be linked to change in EELV. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>