Effects of psychosocial Stress (TSST) on cerebral energy metabolism and food intake.
Not Applicable
- Conditions
- Healthy Subjects
- Registration Number
- DRKS00010439
- Lead Sponsor
- Sektion für PsychoneurobiologieUniversität zu Lübeck
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- Male
- Target Recruitment
- 15
Inclusion Criteria
Body Mass Index 20 - 25kg / qm
Exclusion Criteria
acute/chronic internal, neurologic or psychiatric diseases, alcohol- or nicotinabusus (> 5 cigarettes/d), medication, excessive and competitive sports (z.B. marathon) and extraordinary psychiological and physical stress situations; general exclusion criteria for MRT-Investigations:
metal implants, pacemakers, artificial joints or heart valves, surgical clips, bone screws or plates, pivot teeth, piercing, large colored tattoos, gunshot wounds, severe claustrophobia); Body mass index > 25 kg / qm
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method sing 31-phosphorus magnetic resonance spectroscopy changes in cerebral energy metabolites adenosine triphosphate (ATP) and phosphocreatine (PCr) (3.0 Tesla) were recorded in the magnetic resonance imaging scanner before, while and after stress intervention as well as before while and after no-stress condition.
- Secondary Outcome Measures
Name Time Method The success of the stress intervention is controlled by determining the following blood parameters: ACTH, cortisol, epinephrine and norepinephrine.<br>In addition, the peripheral glucose, insulin and C-peptide are determined.<br>The change in food intake is recorded using standardized established ad libitum buffet.