Evaluation of the effectiveness of the reconsolidation therapy in a clinical population suffering from post-traumatic stress disorder - ULB-PTSD-Propranolol

Hopital Erasme0 个研究点目标入组 68 人开始时间: 2022年11月24日最近更新: 2024年7月22日

适应症

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•Aged 18 to 65, Hospitalized in a psychiatric care unit, French mother tongue, Diagnosed with a state of post-traumatic stress marked by one or more traumas. Patients with PTSD who present with behavioral disorders characterized by difficulty regulating emotions, impulsivity, interpersonal difficulties, feelings of chronic emptiness and abandonment as well as dissociative symptoms are also included in the protocol of research., Women of childbearing potential must be on hormonal contraception or a non-hormonal intrauterine device. Contraception must be maintained throughout the clinical sessions. Inclusion will be after a negative high sensitivity pregnancy test.

•Participants with unstabilized bipolar disorder and/or unstabilized substance dependance and/or with psychiatric disorders like schizophrenia., All contraindications mentioned in section 4.3 of the SmPC., Patients with neurological disorders or cognitive deficits measured by an M.M.S.E. score of less than 27 were not included in the study., Pregnant or lactating women, Asthma, heart problems, diabetes, Basal systolic blood pressure < 100mm Hg, Basal heart rate <55 beats per minute, Previous adverse reaction to a beta-blocker or use of another beta-blocker, Participants are also evaluated by a psychiatrist to rule out any dangerous interaction between taking psychotropic drugs and propranolol., Participants meet with a general physician in order to carry out medical check-up and to exclude any risk to taking propranolol

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