Efficacy of two doses of dexmedetomidine as an adjuvant to intrathecal hyperbaric levobupivacaine in lower limb surgeries - a randomized control trial
Phase 4
- Conditions
- Health Condition 1: T240- Burn of unspecified degree of lower limb, except ankle and footHealth Condition 2: S772- Crushing injury of hip with thighHealth Condition 3: S878- Crushing injury of lower legHealth Condition 4: S723- Fracture of shaft of femurHealth Condition 5: S822- Fracture of shaft of tibiaHealth Condition 6: S760- Injury of muscle, fascia and tendon of hipHealth Condition 7: S828- Other fractures of lower legHealth Condition 8: S798- Other specified injuries of hip and thigh
- Registration Number
- CTRI/2023/11/060207
- Lead Sponsor
- Kalinga Institute of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
? Age between 18-60 years.
? American Society of Anesthesiologists (ASA) physical grade I and II.
? Patients undergoing elective lower limb surgeries.
Exclusion Criteria
?BMI > 30kg/m2
? Patients with known history of allergy to the study medications.
? Patients with coagulative disorders, neurological disorders, hepatic and renal insufficiency.
? Patients unwilling to participate in the study.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Intraoperative analgesia at the desired dermatome level T8 is the primary outcome measure.Timepoint: 15 minutes and 30 minutes, then every <br/ ><br>30 minutes until the block recedes to the desired dematomal level.
- Secondary Outcome Measures
Name Time Method ? The intensity of motor blockade is assessed by the modified Bromage scale. <br/ ><br>? Intraoperative hemodynamic changes in HR, Systolic Blood Pressure (SBP), Diastolic Blood <br/ ><br>Pressure(DBP), Mean Arterial Pressure (MAP) and O2 saturation (SpO2) are assessedTimepoint: 1. Modified Bromage Scale - 15 minutes and 30 minutes, then every <br/ ><br>30 minutes. <br/ ><br>2. SBP,DBP,MAP and SpO2 assessment - at induction and after every 5 mins till 15 mins.