A Comparison of Efficacy between Low-Dose Dexmedetomidine and Propofol for Prophylaxis of Postoperative Delirium in Elderly Patients Undergoing Hip Fracture Surgery: A Randomized Controlled Trial
- Conditions
- Postoperative deliriumPostoperative delirium,Dexmedetomidine, Propofol,Hip surgery
- Registration Number
- TCTR20190522001
- Lead Sponsor
- Ratchadapiseksompod fund
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 108
Age 60 years old or older
- Admit post-operative in ICU
- Closed fracture intertrochanteric or neck of femur
- ASA (American Society of Anesthesiologists) class 2-3
- BMI 18 - 40 kg/m2
- Patient refusal
- Allergy to drugs used in this research
- Richmond Agitation Sedation Scale (RASS) less than - 2 before sedation
- Prior delirium or dementia
- Prior or acute cerebrovascular disease
- Bradycardia eg. Second or Third-degree atrioventricular block
- Prior temporary or permanent pacemaker
- Bradycardia (HR less than 50 bpm) of different origin
- Severe congestive heart failure
- Obstructive sleep apnea
- Severe chronic obstructive pulmonary disease
- Seizure or status epilepticus
- Delirium tremens and alcohol withdrawal
- Substance abuse with acute experience of acute withdrawal
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Incidence of postoperative delirium Postoperative period CAM-IC
- Secondary Outcome Measures
Name Time Method Drugs side effects and complication Postoperative period Medical record,Fentanyl consumption Postoperative period Medical record and recording from patient-controlled analgesia (PCA) machine,Length of hospital stay Postoperative period Medical record,Postoperative Thai Mental State Examination (TMSE) Postoperative period Examine by psychiatrists