Investigating the link between early life stress and multiple long-term health conditions

Not Applicable

Completed

• Conditions: Multi-morbidity between unipolar depression, type 2 diabetes, and coronary heart disease; Not Applicable

• Registration Number: ISRCTN44060592
• Lead Sponsor: European Commission

Brief Summary

2021 Protocol article in https://pubmed.ncbi.nlm.nih.gov/33476328/ (added 26/06/2024) 2023 Results article in https://doi.org/10.1161/HYPERTENSIONAHA.123.21672 Arterial Thickness, Stiffness, and Blood Pressure With Brain Morphology (added 26/06/2024) 2023 Results article in https://doi.org/10.1186/s12916-023-02769-y Depression, cardiometabolic disease, and their co-occurrence after childhood maltreatment (added 26/06/2024) 2023 Results article in https://doi.org/10.2337/dbi23-0010 Obesity (added 26/06/2024) 2022 Results article in https://doi.org/10.1016/j.biopsych.2022.04.022 anorexia nervosa (added 26/06/2024) 2024 Results article in https://doi.org/10.1038/s41598-024-58427-7 depression prediction (added 26/06/2024) 2024 Results article in https://doi.org/10.1016/j.ypmed.2024.107926 early-life stress and adolescent psycho-physical health (added 26/06/2024) 2022 Results article in https://doi.org/10.2337/dc21-1701 maternal glycemic dysregulation during pregnancy and neonatal blood dna methylation (added 26/06/2024) 2023 Results article in https://doi.org/10.1017/S0033291723003264 metabolic Syndrome (added 26/06/2024) 2023 Results article in https://doi.org/10.1371/journal.pgen.1010508 psycho-cardiometabolic multimorbidity (added 26/06/2024)

Detailed Description

Not available

Study Timeline

• Study Start: 2020-07-15
• Study Completion: 2024-06-30
• Last Update Posted: 8 July 2024

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 70000

Inclusion Criteria

Current inclusion criteria as of 28/12/2023:
The inclusion criteria are the same as those of the population studies included in EarlyCause:
1. Generation R: Population-based sample of children
2. ALSPAC: Born of a mother resident in former Avon health authority, expected data of delivery between 1st April 1991 and 31st December 1992
3. NFBCs: Pregnant mothers living in the two northernmost province of Finland (Oulu and Lapland). NFBC-1966 included all mothers with expected date of delivery between 1st of January to 31st December 1966 and their offspring with data at birth, 31 and 46 years of age. NFBC-1986 included mothers with expected date of delivery between July 1985 to June 1986 and their offspring with data at birth and 16 years of age.
4. Rotterdam Study: Adults >55 years
5. NESDA: Adults >18 years with DSM-IV diagnosis of depression (minor or major depression, dysthymia) or anxiety

_____

Previous inclusion criteria:
The inclusion criteria are the same as those of the population studies included in EarlyCause:
1. Generation R, ALSPAC, NFBC: Healthy children at birth
2. Rotterdam: Adults > 55
3. NESDA: Adults > 18 with DSM-IV diagnosis of depression (minor or major depression, dysthymia) or anxiety

Exclusion Criteria

For NESDA, severe mental health (e.g. psychosis, bipolar disorder, obsessive-compulsive disorder, or severe addiction) or disability

Study & Design

• Study Type: Observational
• Study Design: Not specified