Testosterone-Dependent Effects on Protein Biomarkers From Healthy Males Before and After Pharmacological Castration
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 主要终点
- Protein biomarkers
研究概览
简要总结
The study is designed to identify and validate new protein biomarkers in blood related to testosterone activity. Thirty healthy young males underwent pharmaceutical castration to lower testosterone levels. After three weeks the subjects received an intramuscular injection of testosterone undecanoate. Blood samples from just before pharmaceutical castration, three weeks after castration, and one week after injection of testosterone undecanoate were collected representing normal testosterone levels, low testosterone levels, and testosterone at eugonadal levels.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 20 Years 至 30 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 是
入选标准
- •healthy males
排除标准
- •use of anabolic steroids, use of narcotics,
研究组 & 干预措施
Testosterone
A Gonadotropin releasing hormone agonist (GnRH-agonist) is administered to lower the testosterone to castration levels. After four weeks testosterone undecanoate is administered to increase the testosterone to normal levels.
干预措施: GnRH antagonist (Drug)
结局指标
主要结局
Protein biomarkers
时间窗: 48 months
Finding new protein biomarkers related to testosterone response
次要结局
未报告次要终点