The effects of enoxaparin in treatment of esophageal cancer
Phase 2
- Conditions
- Condition 1: Malignant neoplasm of oesophagus. Condition 2: Follow-up examination after combined treatment for malignant neoplasm.Malignant neoplasm of oesophagusFollow-up examination after combined treatment for malignant neoplasm
- Registration Number
- IRCT2016070628814N1
- Lead Sponsor
- Vice chancellor for research, Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Inclusion criteria are definitive diagnoses of esophageal cancer by oncologist and pathological evaluation, non-metastatic esophageal cancer, patient who are candidate for chemo-radiation treatment, pathological report of SCC, normal CBC, normal kidney function test, normal liver function test, normal FBS.
Exclusion criteria are previous history of chest wall radiotherapy, previous history of chemotherapy, past medical history of HTN, DM, renal failure and liver failure, pathological report of adenocarcinoma or small cell carcinoma, neoplasm of other organs, discontent for the study, inability to do daily radiotherapy, unwillingness to esophagectomy.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Clinical responce. Timepoint: 4-6 weeks after complete of combined treatment. Method of measurement: according to endoscopic findings (no lesion, primary lesion or became smaller less than 50%of primary lesion, become smaller more than 50% of primary lesion).;Pathologic responce. Timepoint: 4-6weeks after complete of treatment. Method of measurement: according to pathologic findigs of esophagous specimen (complete Vs incompelet).;R staging (residual of tumor). Timepoint: intraoperative of eosophagectomy. Method of measurement: according to surgeon findigs when eosophagectomy is done (gross residue, microscopic residue, without residue).
- Secondary Outcome Measures
Name Time Method Heparin induced thrombocytopenia. Timepoint: before prescription of any course of chemotherapy. Method of measurement: according to CBC.