Sinonasal pathology in children with Cystic Fibrosis

Completed

• Conditions: 10046304; Cystic Fibrosis; mucoviscidosis; 10004018; rhinosinusitis; 10038686

• Registration Number: NL-OMON38689
• Lead Sponsor: HagaZiekenhuis

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 11 June 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 60

Inclusion Criteria

* Confirmed diagnose of Cystic Fibrosis based on genotyping or a positive sweat test
* Age * 0 and <18 years

Exclusion Criteria

* Gross immunodeficiency (congenital of acquired)
* Congenital mucociliary problems other than CF (e.g. Primairy ciliary dyskinesia)
* ASA syndrome (Samter*s triad; nasal polyps, asthma, and aspirin sensitivity)
* Intranasal neoplasia
* Systemic vasculitis and granulomatous diseases (e.g. M. Wegener, sarcoidosis, Churg-Strauss syndrome)
* Recently (within 1 month) CT-sinus performed

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Lund-Mackay scores on CT-sinus in children with CF. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Secondary study parameters will be the outcome of nasal cultures, symptoms of<br /><br>sinonasal disease and anatomic variations in the sinonasal area. </p><br>