Foetal programming of allergic diseases

Not Applicable

Completed

• Conditions: Allergic diseases, e.g., atopic dermatitis, asthma and allergic rhinoconjuncitvitis; Injury, Occupational Diseases, Poisoning; Adverse effects, not elsewhere classified

• Registration Number: ISRCTN97827633
• Lead Sponsor: Individual sponsor (Germany)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2009-04-20
• Last Update Posted: 17 October 2016

Recruitment & Eligibility

• Status: Completed
• Sex: Female
• Target Recruitment: 1300

Inclusion Criteria

1. Pregnant women recruited at a gestational age of 8 - 12 weeks
2. Aged between 18 and 35 years old
3. Single child pregnancy
4. Full-term deliveries

Exclusion Criteria

1. Fertility treatments and infections (human immunodeficiency virus [HIV], hepatitis B and C)
2. A history of recurrent spontaneous abortion, pre-eclampsia, or gestational diabetes in previous pregnancies
3. Sufferers of the following chronic diseases:
3.1. Inflammatory bowel diseases
3.2. Diabetes type 1
3.3. Rheumatoid and autoimmune diseases
3.4. Previous chemotherapies and radiation therapies

Study & Design

• Study Type: Observational
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluation of environmental cues as further potential risk factors during pregnancy (e.g. living conditions, smoking habits, perceived stress, social support and nutrition) for the child's risk to develop an atopic disease.

Secondary Outcome Measures

Name	Time	Method
Investigation of potential mechanism, by which environmental cues may exert a foetal programming effect towards allergic diseases during pregnancy. Here we will concentrate on endocrine, immune and neurobiological mechanisms.