Zinc and Exercise for the Treatment of Insulin Resistance

Recruiting

• Conditions: Type 2 Diabetes Mellitus; Metabolic and Endocrine - Diabetes

• Registration Number: ACTRN12615000157572
• Lead Sponsor: niversity of Otago

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-02-18
• Last Update Posted: 13 January 2020

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Patients diagnosed with type 2 DM who are physically inactive (n=30)

Exclusion Criteria

Exclusion criteria include: habitual smokers, women who are pregnant or breastfeeding, those with diagnosis of any other major illness, the use of vitamins or mineral supplements in the last 6 weeks and medical contraindication to maximal exercise testing or exercise training.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Insulin sensitivity by hyperinsulinemic, euglycaemic clamp[Week 0, Week 6, Week 8];Glycaemic control (fasting serum glucose, insulin)[Week 0, Week 6, Week 8]

Secondary Outcome Measures

Name	Time	Method
ipidemia (fasting serum total cholesterol, LDL, HDL, triglycerides)[Week 0, Week 6, Week 8];Gene expression of zinc transporters and metallothionein in peripheral blood mononuclear cells and skeletal muscles by real time PCR[Week 0, Week 6, Week 8];Expression of mediators of insulin signaling pathways in skeletal muscles by Western blot or similar[Week 0, Week 6, Week 8]