Allopurinol as an Adjunctive Therapy in Patients with Bipolar Mania
- Conditions
- Health Condition 1: F312- Bipolar disorder, current episodemanic severe with psychotic features
- Registration Number
- CTRI/2023/10/058864
- Lead Sponsor
- Central Institute Of Psychiatry
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Open to Recruitment
- Sex
- Not specified
- Target Recruitment
- 0
1. Male inpatients satisfying the ICD 10-DCR[1993] criteria of Bipolar affective
disorder, current episode mania with psychotic symptoms with YMRS score of >20
and HAMD score <7
2. Age group of 18-50 years.
3. Drug naive or drug free patients for minimum 2 weeks for mood
stabilizers/antipsychotics and 4 weeks for depot antipsychotics.
4. Those who give informed consent for participating in the study.
1. Any other major co-morbid psychiatric diagnosis and substance dependence excluding
nicotine & caffeine.
2. Significant current/ past medical or neurological illness including severe hepatic disease
and history of severe head injury.
3. Patients taking antipurinergic drugs for other medical conditions.
4. Known hypersensitivity to Tab. Allopurinol or any of its components.
5. Patients who had received ECT in last 6 months.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Effectiveness Of Allopurinol (600MG/Day)as an Adjunctive Therapy as Assessed ON YMRS, BPRS, and ,OAS-M ,HAMDTimepoint: Baseline And 4 Weeks
- Secondary Outcome Measures
Name Time Method CHANGE IN SERUM URIC ACID LEVEL IN PATIENTS RECEIVING TAB ALLOPURINOL 600MG/DAYTimepoint: BASELINE AND 4 WEEKS