NCT04083430进行中（未招募）4 期
Cytotoxicity of Yellow Fever Specific CD8 T Cells Following YF-17D Vaccination
适应症
干预措施
相关药物
试验速览
- 阶段
- 4 期
- 状态
- 进行中（未招募）
- 入组人数
- 60
- 试验地点
- 1
- 主要终点
- Incidence of cytotoxicity of the yellow fever specific (NS4B214LLWNGPMAV222) CD8 T cells 21(+/-3) days after vaccination with YF-17D
研究概览
简要总结
Investigating cytotoxicity of yellow fever specific CD8 T cells following YF-17D vaccination and the following licensing of these epitope-specific CD8 T cells
详细描述
CD: cluster of differentiation YF: yellow fever
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 60 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Age between 18 to 60 years
- •Informed consent given
排除标准
- •Fever (orally >37,5 C) on day of vaccination
- •Immunosuppressants
- •Pregnant or breast feeding
- •Severe immunodeficiency
- •Known thymus dysfunction
- •Allergy against egg
- •Known haemophilia
- •Previous severe reaction to vaccine
- •Not willing to use anticonceptives 4 weeks after vaccination
研究组 & 干预措施
Vaccine
Other
Yellow Fever Vaccine
干预措施: Yellow Fever Vaccine (Drug)
结局指标
主要结局
Incidence of cytotoxicity of the yellow fever specific (NS4B214LLWNGPMAV222) CD8 T cells 21(+/-3) days after vaccination with YF-17D
时间窗: 21(+/-3) days
Measured by flow cytometry
Incidence of cytotoxicity of the yellow fever specific (NS4B214LLWNGPMAV222) CD8 T cells 100 (+/- 40) days after vaccination with YF-17D
时间窗: 100 (+/- 40) days
Measured by flow cytometry
次要结局
- % of patients with novel yellow fever vaccine epitopes according to HLA-type defining optimal timepoint for T cell licensing(100 (+/- 40) days)
- Proportion of target cells killed ex vivo from in vivo generated YF-specific CD8+ T cells(100 (+/- 40) days)
研究者
研究点 (1)
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