Clinical Features and Outcome of Wilson's Disease With Generalized Epilepsy in Chinese Patients

Completed

• Conditions: Generalized Epilepsy; Wilson Disease
• Interventions: Genetic: genetic test

• Registration Number: NCT04965571
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

Generalized epilepsy is rarely reported in patients with Wilson disease (WD) and lacks experience in clinical practice. We aim to provide better experience for the diagnosis and treatment for WD patients with epilepsy in the future.

Detailed Description

A retrospective study was performed in 13 Chinese WD patients with generalized epilepsy. Each patient was diagnosed with WD by clinical evaluation and genetic screening. Patients were given small doses of antiepileptic drugs (AEDs), followed by copper-chelation therapy when the seizures stabilized. Clinical manifestations, brain imaging changes, and treatment and outcome after a long-term follow-up were analyzed.

Study Timeline

• Study Start: 2010-09-01
• Primary Completion: 2017-09-01
• Study Completion: 2019-03-01
• Status Verified: 2021-07
• Study First Submitted: 2021-07-05
• Study First Submitted QC: 2021-07-11
• Last Update Submitted: 2021-07-11
• Study First Posted: 2021-07-16
• Last Update Posted: 2021-07-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 13

Inclusion Criteria

• Each patient was diagnosed with WD by clinical evaluation and genetic screening and had ever experienced generalized epilepsy

Exclusion Criteria

• Not WD & without generalized epilepsy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
WD-seizures	genetic test	Chinese WD patients with generalized epilepsy

Primary Outcome Measures

Name	Time	Method
Number of participants with treatment stop seizures attacks	12 month	After standard treatment, the patients would stop attacks and get improved.

Secondary Outcome Measures

Name	Time	Method
Number of participants with treatment have improved brain MRI	12 month	After standard treatment, the abnormalities of brain MRI would get better in patients.

Trial Locations

Locations (1)

Second Affiliated Hospital of Zhejiang University School of Medicine; 🇨🇳 Hangzhou, Zhejiang, China