Candesartan/Hydrochlorothiazide Versus High-dose Candesartan for the Clinical Assessment of N-terminal pro-B Type Natriuretic Peptide Levels and Cardio-renal Protective Effects: A comparative study
Not Applicable
- Conditions
- Hypertension
- Registration Number
- JPRN-UMIN000005252
- Lead Sponsor
- Juntendo University School of Medicine, Department of Cardiovascular Medicine
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
1. Patients with a history of hypersensitivity to the study drugs 2. Patients with a history of hypersensitivity to thiazide or thiazide-like diuretics 3. Patients with chronic renal failure (serum creatinine => 2.0 mg/dL) 4. Patients with anuria or on dialysis 5. Patients with acute renal failure 6. Patients whose levels of sodium and/or potassium are obviously low 7. Patients who are pregnant, possibly pregnant, or lactating
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. The achievement rate of blood pressure targets measured at home (home BP) and at the outpatient department according to the Japanese Society of Hypertension (JSH) 2009 criteria 2. Changes in the levels of cardio-renal associated markers, inflammatory markers and glucose metabolism
- Secondary Outcome Measures
Name Time Method Changes in 24-h ambulatory blood pressure, lipids, microalbuminuria, uric acid, and serum potassium