Association Between Different Blood Groups and Sepsis in Preterm Infants

• Conditions: Prematurity; Sepsis; Blood Group Antigen Abnormality
• Interventions: Diagnostic Test: Diagnosis

• Registration Number: NCT03734978
• Lead Sponsor: Ufuk Cakir

Brief Summary

To investigate whether there is a relationship between sepsis and blood groups in preterm infants.This retrospective cohort study included preterm neonates born at \<32 weeks of gestation with a birth weight \<1500 g. Neonates were grouped by blood type (O, A, B, AB) and sepsis were compared among these groups.

Detailed Description

This retrospective study was conducted on data collected between 1 January 2011 and 31 August 2018 in the neonatal intensive care unit (NICU) of the Health Sciences University Zekai Tahir Burak Women's Health Education and Research Hospital.

Neonates born at GA \<32 weeks with birth weight (BW) \<1500 g were included in the study.

Data pertaining to the neonates were recorded from medical records for each patient, and their ABO blood type was recorded.

The neonates were grouped by blood type (O, A, B, AB) and also separated into non-O (A, B, AB) and O groups and non-A (O, B, AB) and A groups for comparison of early and late onset sepsis.

Study Timeline

• Status Verified: 2018-11
• Study First Submitted: 2018-11-02
• Study First Submitted QC: 2018-11-06
• Last Update Submitted: 2018-11-06
• Study First Posted: 2018-11-08
• Last Update Posted: 2018-11-08
• Study Start: 2018-12-15
• Primary Completion: 2019-02-01
• Study Completion: 2019-10-31

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

• Preterm neonates born at <32 weeks of gestation with a birth weight <1500 g.

Exclusion Criteria

• Neonates born with severe congenital defects, birth weight ≥1500 g and gestational age ≥32 weeks were excluded.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
O blood group	Diagnosis	prematurity with sepsis
B blood group	Diagnosis	prematurity with sepsis
AB blood group	Diagnosis	prematurity with sepsis
A blood group	Diagnosis	prematurity with sepsis

Primary Outcome Measures

Name	Time	Method
Association Between Different Blood Groups and Sepsis in Preterm Infants	Through study completion, an average of 3 month	The neonates were grouped by blood type (O, A, B, AB) and also separated into non-O (A, B, AB) and O groups and non-A (O, B, AB) and A groups for comparison of demographic characteristics, clinical features, and sepsis.

Trial Locations

Locations (1)

Zekai Tahir Burak Hospital; 🇹🇷 Ankara, Turkey