Dynamics of the innate, cellular and humoral immune response in healthy persistent, intermittent and noncarriers of Staphylococcus aureus

Recruiting

• Conditions: Nasal colonisation Staphylococcus aureus; 10004018

• Registration Number: NL-OMON30541
• Lead Sponsor: Erasmus MC, Universitair Medisch Centrum Rotterdam

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 400

Inclusion Criteria

Healthy individuals older than 18 years
The volunteer has given informed consent

Exclusion Criteria

Individuals with age below 18 years
Volunteers with diabetes mellitus, renal insufficiency, COPD, heart diseases, immunocompromised status (HIV, AIDS) or use of immunosuppressants, skin diseases like eczema and psoriasis.

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. The amount of persistent, intermittent and noncarriers<br /><br>2. The qualitative or quantitative difference in the presence of<br /><br>antistaphylococcal IgG, IgM and IgA between healthy persistent, intermittent<br /><br>and noncarriers of S. aureus in blood or nasal secretion<br /><br>3. The qualitative or quantitative difference in the presence of CD4+ and CD8+<br /><br>T cells between healthy persistent, intermittent and noncarriers of S. aureus<br /><br>in blood<br /><br>4. The difference in protein composition of nasal secretion between healthy<br /><br>persistent, intermittent and noncarriers of S. aureus<br /><br>5. The qualitative or quantitative difference in the presence of<br /><br>antistaphylococcal antibodies and cellular immune response between healthy<br /><br>individuals compared to patients with a bacteremia caused by S. aureus</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Not applicable</p><br>