CTRI/2018/02/012230已完成不适用
Assessment of Coagulation Profile and Haematopoietic Responses in Patients With Acute-on-chronic Liver Failure During Systemic Inflammatory Response (SIRS) and Sepsis
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Prevalence and severity of coagulation profile derangement and haematopoietic responses, by sonoclot/ TEG, coagulation and hematological parameters, in acute- on-chronic liver failure with and without systemic inflammatory response.
研究概览
简要总结
Dynamic coagulation derangements, measured by thromboelastography, determine the likelihood of bleeding, sepsis and mortality in ACLF (Acute on Chronic Liver Failure).
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •Age 18-65 years 2)ACLF (Acute on Chronic Liver Failure), as diagnosed by APASL (Asian Pacific association of Study of Liver Disease) criteria mentioned above.
排除标准
- •Patients with evidence of sepsis at presentation.
- •Current therapy: Recent blood or blood component transfusion in the last 2 days.
- •HIV positive/ AIDS patients 4)Patients requiring anti platelet therapy, 5)Renal insufficiency requiring dialysis 6)Active malignancy within the last 5 years 7)Patient with other neurological disease and metabolic disorders, unbalanced heart failure and/or respiratory failure or end-stage renal disease 8)Administration of anticoagulants, antifibrinolytics, 9)Not willing to participate in the study Pregnancy.
结局指标
主要结局
Prevalence and severity of coagulation profile derangement and haematopoietic responses, by sonoclot/ TEG, coagulation and hematological parameters, in acute- on-chronic liver failure with and without systemic inflammatory response.
时间窗: 0 day, 3 day and 7 day after admission
次要结局
- Utility of sonoclot/ TEG in predicting blood product utilization.(0 day, 3 day and 7 day after admission)
- Sonoclot/TEG result indicating hypocoagulability correlates with the patients tendency to bleed in ACLF(0 day, 3 day and 7 day after admission)
- Changes in baseline coagulation profile can predict development of sepsis in patients of ACLF.(0 day, 3 day and 7 day after admission)
- Coagulation dysfunction (prothrombotic and anticoagulant tendencies) in patients with ACLF with or without evidence of sepsis.(0 day, 3 day and 7 day after admission)
- Effect of sepsis on the haematopoietic response of patients with Acute on Chronic Liver Failure.(0 day, 3 day and 7 day after admission)
研究者
研究点 (1)
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