Effect of propionate on mesenteric adipose tissue and insulin sensitivity

Not Applicable

• Conditions: Metabolic disease; Nutritional, Metabolic, Endocrine

• Registration Number: ISRCTN11187912
• Lead Sponsor: Imperial College London

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2023-07-27
• Last Update Posted: 21 August 2023
• Study Completion: 2025-05-11

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 56

Inclusion Criteria

In vivo study:
1. The participants on the waiting list for cholecystectomy
2. Male or female
3. Age between 18-75 years (inclusive)
4. Body mass index (BMI) of 18-35 kg/m2
5. Willingness and ability to give written informed consent and willingness and ability to understand, participate and comply with the study requirements

In vitro study:
1. The participants on the surgery waiting list of the team with Dr Madhava Pai
2. Male or female
3. Age between 18-75 years (inclusive)
4. Body mass index (BMI) of 18-35 kg/m2
5. Willingness and ability to give written informed consent and willingness and ability to understand, participate and comply with the study requirements

Exclusion Criteria

In vivo study:
1. Abnormal ECG
2. Screening blood results outside of normal reference values
3. Weight change of =3 kg in the preceding 2 months
4. Current smokers
5. History of substance abuse and/or excess alcohol intake
6. Pregnancy
7. Formal medical diagnosis of Type 2 Diabetes, Cardiovascular disease, Cancer, Gastrointestinal disease (e.g. inflammatory bowel disease or irritable bowel), Kidney disease, Liver disease and Pancreatitis
8. Participation in a research study in the 12-week period prior to entering this study
9. Any blood donation within the 12-week period prior to entering this study
10. Use of antibiotics in the past 3 months
11. New medication in the past 3 months
12. Any other reason in the opinion of the investigator

In vitro study
1. Screening blood results outside of normal reference values
2. Weight change of = 3kg in the preceding 2 months
3. History of substance abuse and/or excess alcohol intake
4. Pregnancy
5. Any other reason in the opinion of the investigator

Study & Design

• Study Type: Interventional
• Study Design: Not specified