tDCS Effects on Associative Learning in Younger Adults
- Conditions
- Associative Learning
- Registration Number
- NCT02795715
- Lead Sponsor
- Charite University, Berlin, Germany
- Brief Summary
The aim of this study is to investigate whether a tDCS-accompanied training of audio-visual associative memory leads to a performance improvement in healthy older individuals."
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- WITHDRAWN
- Sex
- All
- Target Recruitment
- Not specified
- Age: young (18-30 years)
- Right handedness
- unobtrusive neuropsychological screening
- Mild cognitive impairment (MCI) or other neurological diseases.
- History of severe alcoholism or use of drugs.
- Severe psychiatric disorders such as depression, psychosis (if not in remission) and severe untreated medical problems.
- Contraindication for MRI (claustrophobia, metallic implants, ferromagnetic metals in the body, disorders of thermoregulation, pregnant women).
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- CROSSOVER
- Primary Outcome Measures
Name Time Method Performance in a verbal associative learning paradigm under anodal tDCS compared to sham tDCS. assessed immediately after training period (several learning blocks) compared to sham Investigation whether anodal tDCS leads to improved performance accuracy in the Wernicko task compared to sham stimulation.
- Secondary Outcome Measures
Name Time Method Genotyping of learning related polymorphisms assessed during baseline screening To assess predictors of positive reaction to brain stimulation, genotyping of several learning related polymorphisms will be performed
Structural predictors assessed during baseline testing Microstructure of white matter (Fractional Anisotropy) as measured by diffusion tensor imaging during baseline as predictors for performance and tDCS responsiveness
Other cognitive outcomes: Attention performance assessed directly before and immediately after tDCS + training compared to sham Digit span forward performance assessed before and after stimulation to test for tDCS effects on attention
Other cognitive outcomes: working memory performance assessed directly before and immediately after tDCS + training compared to sham Digit span backward performance assessed before and after stimulation to test for tDCS effects on working memory
Functional connectivity predictors assessed during baseline testing Connectivity as measured by resting-state fMRI during baseline as predictors for performance and tDCS responsiveness
Trial Locations
- Locations (1)
Charité Universitätsmedizin Berlin
🇩🇪Berlin, Germany
Charité Universitätsmedizin Berlin🇩🇪Berlin, Germany