The Efficacy of Chlorella Supplementation on Health and Performance Following a 12-week Training Programme
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 36
- 试验地点
- 2
- 主要终点
- Changes in cardiovascular fitness (VO2max)
研究概览
简要总结
Algae are an emerging functional food source that are gaining traction and popularity in biopharmaceutical, nutraceutical, and biotechnology industries. They are a diverse and complex species that comprise an abundant breadth of micronutrients (multiple vitamins, minerals, fatty acids, and amino acids) that can possibly promote human health. One such popular algae is chlorella, a unicellular dark green organism, which can be readily bought in health stores worldwide. Although there is some promising data to suggest chlorella supplementation can alleviate cardiovascular risk factors and improve VO2max from supplementation alone, an area which has particularly limited existing literature is the possible ergogenic and health influence of chlorella supplementation combined with a controlled training programme in sedentary and overweight populations. Given that such populations are susceptible to increased risk of developing associated diseases (cardiovascular disease, diabetes, hypertension) and possess poor diets, there is a need to investigate the possible synergistic effect of a training programme and supplementation of algae further. Furthermore, there is growing evidence to suggest that supplementation with algae may have a beneficial effect on cognitive function, primarily owed to antioxidant and anti-inflammatory mechanisms. Therefore, the purpose of this study aims to assess the efficacy of chlorella supplementation on VO2max, blood lipid profiles, cognitive function and body composition following a 12-week training programme. Briefly, in a double blind, randomised, placebo-controlled trial, participants will be randomly allocated into 1 of 4 groups (A. Exercise + Chlorella, B. Exercise + Placebo, C. Control + Chlorella, D. Control + Placebo).
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Treatment
- 盲法
- Double (Participant, Investigator)
盲法说明
Double
入排标准
- 年龄范围
- 18 Years 至 50 Years(Adult)
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 18-50
- •Classified a sedentary (<30 minutes of moderate intensity exercise for <3 days per week for 3 months) and/or overweight (BMI = 25 +)
- •Be willing to complete a 12-week training programme
排除标准
- •Individuals taking blood thinners.
- •Known allergies to algae/mould and iodine.
- •Taking immunosuppressant medication
- •Regularly ingesting algae
结局指标
主要结局
Changes in cardiovascular fitness (VO2max)
时间窗: At baseline, week 6 and at week 12
Changes in cardiovascular fitness variables as measured by a Cardio Pulmonary Exercise Test.
Changes in blood lipid profiling
时间窗: At baseline, week 6 and at week 12
Assessing changes in blood lipids (Triglycerides, cholesterol, low-density lipoprotein, High-density lipoprotein)
次要结局
- Changes in cognitive function (inhibition)(At baseline, week 6 and at week 12 (before and after exercise))
- Changes in blood pressure(At baseline, week 6 and at week 12)
- Changes in augmentation index(At baseline, week 6 and at week 12)
- Changes in cognitive function (simple reaction time)(At baseline, week 6 and at week 12 (before and after exercise))
- Changes in cognitive function (context memory)(At baseline, week 6 and at week 12 (before and after exercise))
- Changes in cognitive function (spatial anticipation)(At baseline, week 6 and at week 12 (before and after exercise))
- Changes in body composition variables(At baseline, week 6 and at week 12)
- Changes in cognitive function (endogenous and exogenous attending)(At baseline, week 6 and at week 12 (before and after exercise))
- Changes in body composition variables (fat & lean mass percentage)(At baseline, week 6 and at week 12)
- Changes in body composition variables (fat free and muscle mass)(At baseline, week 6 and at week 12)
- Changes in pulse wave velocity(At baseline, week 6 and at week 12)
- Changes in total vascular resistance(At baseline, week 6 and at week 12)
- Changes in augmentation pressure(At baseline, week 6 and at week 12)
- Changes in lactate(At baseline, week 6 and at week 12)
- Changes in biomarkers for brain health(At baseline, week 6 and at week 12)
- Changes in Nitrate/Nitrite(At baseline, week 6 and at week 12)
