Computer-Assisted Cognitive Remediation in Schizophrenia: Individualized versus generic exercise pla

Phase 4

• Conditions: F20; Schizophrenia

• Registration Number: DRKS00021628
• Lead Sponsor: Abteilung für Psychiatrie und Psychotherapie SRH Klinikum Karlsbad-Langensteinbach

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Completion: 2015-12-03
• Study Start: 2020-05-11
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Complete
• Sex: All
• Target Recruitment: 59

Inclusion Criteria

(1)Patients should meet DSM-IV criteria for schizophrenia (295.1-295.3; 295.6; 295.9) confirmed with the MINI
(2)Age between 18 and 55 years
(3)IQ> 80 according to the Mehrfachwahl-Wortschatztest
(4)No current substance abuse (standard drug screening in urine)
(5)No documented or suspected major brain damage or other neurological diseases (e.g. stroke, epilepsy, concussion)
(6)Patients must be clinically stable and able to provide informed consent

Exclusion Criteria

(1)Patients with Positive and Negative Syndrome Scale scores = 5 for any positive symptom item will be excluded to avoid confounding with acute psychotic symptoms
(2)Patients with Hamilton Rating Scale for Depression scores = 20 will be excluded to avoid confounding with severe depressive symptoms
(3)Cognitive deficits: in at least three domains scores below PR<16 (WAFA, WAFG, WAFS, NBV, ToL, Go/NoGo)

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
europsychological performance, psychopathology and functional outcome were assessed at baseline and post-treatment. <br><br>Psychopathology und demographics: PANSS, HAMD, M.I.N.I-SKID (only baseline), BDI, MWT-B (only baseline)<br><br>Functional outcome: <br>GAF, MINI-ICF-APP, SLOF<br><br>Neuropsychological performance: alertness, divided attention, selective attention, working memory, planning, response inhibition