Cognitive remediation for young people with schizophrenia

Completed

• Conditions: Schizophrenia; Mental and Behavioural Disorders

• Registration Number: ISRCTN75187865
• Lead Sponsor: King's College London (UK)

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2006-05-05
• Last Update Posted: 13 January 2015

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 40

Inclusion Criteria

1. A diagnosis of schizophrenia according to the Diagnostic and Statistical Manual, 4th (DSM IV); had a first episode while still a teenager and their duration of illness was 3 years or less
2. Cognitive difficulties in cognitive flexibility (below the 16th centile on the Wisconsin Card Sort Test) and/or memory (poor performance on the Rivermead Behavioural Memory Test)
3. Difficulties in social functioning (at least one problem on the Social Behaviour Scale)
4. Stable medication, in terms of type and dose, for at least one month prior to inclusion

Exclusion Criteria

1. Evidence of organic brain disorder (e.g. epilepsy)
2. A diagnosis of current substance abuse as defined by the DSM IV
3. A plan to change medication during the trial

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. Cognitive flexibility (number of categories achieved on the Wisconsin Card Sort Test [WCST] Heaton et al.)<br>2. Memory (raw score from Digit Span: Wechsler Adult Intelligence Scale-III [WAIS-III] Wechsler,1981)<br>3. Planning (modified six elements)

Secondary Outcome Measures

Name	Time	Method
1. Social Behaviour Schedule ([SBS] Wykes and Sturt, 1986) for social functioning<br>2. Brief Psychiatric Rating Scale (for symptoms) using Lukoff et al. version and Shaffer Factor Scores<br>3. Quality of Life Scale (for social inclusion)<br>4. Rosenberg Self Esteem Scale (Rosenberg, 1965)