Vitamin D & Levothyroxine Combination Versus Levothyroxine on Lipid Profile in Hypothyroidism
Phase 3
Completed
- Conditions
- Hypothyroidism PrimaryLipid DisorderDyslipidemias
- Interventions
- Registration Number
- NCT06276205
- Lead Sponsor
- King Edward Medical University
- Brief Summary
The goal of this clinical trial is to study the improvement of lipid levels in hypothyroid individuals after staring treatment.
The main question it aims to answer is:
• whether adding Vitamin D to standard therapy has any additional benefits
Participants will be given Vitamin D in replacement doses according to their pre-existing Vitamin D level in addition to levothyroxine.
Researchers will compare them with another group receiving only levothyroxine to see how much lipids improve in them
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 62
Inclusion Criteria
- Patients of all genders.
- Age more than 12 years
- Biochemically hypothyroid (overt & subclinical)
- Vitamin D level between 10-70ng/ml
- TC <250mg/dl, LDL 70-144mg/dl, TGs 150-499mg/dl
Exclusion Criteria
- Known Atherosclerotic Cardiovascular Disease
- BMI>35kg/m2
- History of Alcoholism (>14 units/day)
- History of Beta blocker intake
- Patient taking lipid lowering drugs
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Arm && Interventions
Group Intervention Description Vitamin D + Levothyroxine Levothyroxin - Vitamin D + Levothyroxine Vitamin D - Levothyroxine Alone Levothyroxin -
- Primary Outcome Measures
Name Time Method Decline in Total Cholesterol 24 weeks \>9% decline from baseline
Decline in LDL 24 weeks 14% decline in LDL-C from baseline \>14% decline from baseline
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
King Edward Medical University
🇵🇰Lahore, Punjab, Pakistan