Levothyroxine
- Generic Name
- Levothyroxine
- Brand Names
- Eltroxin, Ermeza, Euthyrox, Levo-T, Levothroid, Levoxyl, Np Thyroid, Synthroid, Thyquidity, Tirosint, Unithroid
- Drug Type
- Small Molecule
- Chemical Formula
- C15H11I4NO4
- CAS Number
- 51-48-9
- Unique Ingredient Identifier
- Q51BO43MG4
- Background
Levothyroxine is a synthetically produced form of thyroxine, a major endogenous hormone secreted by the thyroid gland. Also known as L-thyroxine or the brand name product Synthroid, levothyroxine is used primarily to treat hypothyroidism, a condition where the thyroid gland is no longer able to produce sufficient quantities of the thyroid hormones T (tetraio...
- Indication
Levothyroxine is indicated as replacement therapy in primary (thyroidal), secondary (pituitary) and tertiary (hypothalamic) congenital or acquired hypothyroidism. It is also indicated as an adjunct to surgery and radioiodine therapy in the management of thyrotropin-dependent well-differentiated thyroid cancer.
- Associated Conditions
- Edematous Fibrosclerotic Panniculopathy (Cellulite), Hypothyroidism, Localized Adiposity, Myxedema coma, Euthyroid Goitre, Thyrotropin dependent Well-Differentiated Thyroid Cancer
- Associated Therapies
- -
Novel Approaches to the Treatment of Hypothyroidism
- Conditions
- Interventions
- First Posted Date
- 2024-12-12
- Last Posted Date
- 2024-12-12
- Lead Sponsor
- UConn Health
- Target Recruit Count
- 90
- Registration Number
- NCT06731764
- Locations
- 🇺🇸
UConn Health, Farmington, Connecticut, United States
Role of Levothyroxine Supplementation in Delayed Recovery Following Cardiac Surgery
- Conditions
- Interventions
- First Posted Date
- 2024-10-28
- Last Posted Date
- 2024-10-28
- Lead Sponsor
- Ain Shams University
- Target Recruit Count
- 50
- Registration Number
- NCT06660823
- Locations
- 🇪🇬
Faculty of Medicine ,Ain Shams University, Cairo, Egypt
Effect of HCQ Combined With LT4 on LBR in Euthyroid Women With URPL and TPO-Ab
- Conditions
- Interventions
- First Posted Date
- 2024-10-22
- Last Posted Date
- 2024-10-22
- Target Recruit Count
- 796
- Registration Number
- NCT06652113
- Locations
- 🇨🇳
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China
A Study of Levothyroxine and Enlicitide Decanoate (MK-0616) in Healthy Adult Participants (MK-0616-028)
- First Posted Date
- 2024-10-03
- Last Posted Date
- 2024-10-03
- Lead Sponsor
- Merck Sharp & Dohme LLC
- Target Recruit Count
- 28
- Registration Number
- NCT06625814
- Locations
- 🇺🇸
Celerion (Site 0001), Lincoln, Nebraska, United States
Levothyroxine-sodium Bioequivalence Trial With Oral Single Dose Administration
- First Posted Date
- 2024-08-09
- Last Posted Date
- 2024-08-09
- Lead Sponsor
- Berlin-Chemie AG Menarini Group
- Target Recruit Count
- 132
- Registration Number
- NCT06547242
- Locations
- 🇩🇪
Phase I Unit, Erfurt, Thuringia, Germany
Correlation Between Levothyroxine and Blood Th17/Treg in Pregnant Women With Normal-high TSH and Positive TPOAb
- First Posted Date
- 2024-07-30
- Last Posted Date
- 2024-07-30
- Target Recruit Count
- 64
- Registration Number
- NCT06527859
- Locations
- 🇨🇳
The Third Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Levothyroxine Supplementation for Heart Transplant Recipients
- Conditions
- Interventions
- First Posted Date
- 2024-05-24
- Last Posted Date
- 2024-05-31
- Lead Sponsor
- University of California, San Francisco
- Target Recruit Count
- 97
- Registration Number
- NCT06428097
- Locations
- 🇺🇸
University of California, San Francisco, San Francisco, California, United States
Efficacy of Thyroid Hormone Replacement for Secondary Hypothyroidism Following Intracerebral Hemorrhage
- Conditions
- Interventions
- First Posted Date
- 2024-04-09
- Last Posted Date
- 2024-04-09
- Lead Sponsor
- Peking Union Medical College Hospital
- Target Recruit Count
- 100
- Registration Number
- NCT06353555
- Locations
- 🇨🇳
Peking union medical college hospital, Beijing, Beijing, China
A Study to Assess the Safety and Efficacy of Oral Armour Thyroid Compared to Synthetic T4 for the Treatment of Primary Hypothyroidism in Adult Participants
- First Posted Date
- 2024-04-03
- Last Posted Date
- 2024-12-19
- Lead Sponsor
- AbbVie
- Target Recruit Count
- 2800
- Registration Number
- NCT06345339
- Locations
- 🇺🇸
Scripps Whittier Diabetes Institute /ID# 259215, La Jolla, California, United States
🇺🇸Facey Medical Foundation /ID# 260863, Mission Hills, California, United States
🇺🇸Hoag Memorial Hospital Presbyterian /ID# 260990, Newport Beach, California, United States
Vitamin D & Levothyroxine Combination Versus Levothyroxine on Lipid Profile in Hypothyroidism
- Conditions
- Interventions
- First Posted Date
- 2024-02-23
- Last Posted Date
- 2024-02-23
- Lead Sponsor
- King Edward Medical University
- Target Recruit Count
- 60
- Registration Number
- NCT06276205
- Locations
- 🇵🇰
King Edward Medical University, Lahore, Punjab, Pakistan
Drug Development Updates
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