Pharmacogenomic Research in Korean Populatio
Not Applicable
Completed
- Conditions
- Endocrine, nutritional and metabolic disease
- Registration Number
- KCT0001119
- Lead Sponsor
- ational Institute of Food and Drug Safety Evaluation
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 40
Inclusion Criteria
1.Individuals with the aforementioned 4 different SLCO1B1 and ABCB1 genotypes confirmed by pre-genotyping
2.Non-smoker,non-heavy drinker
3.Not administration of other drugs
4.Healthy volunteers confirmed by physical and laboratory examination
5.Informed consent provided
Exclusion Criteria
1.Individuals with other than the aforementioned 4 different SLCO1B1 and ABCB1 genotypes confirmed by pre-genotyping
2.Smoker or heavy drinker
3.Coadministration of other drugs
4.Not healthy from laboratory or physical examination
5.Informed consent not provided
Study & Design
- Study Type
- Interventional Study
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method simvastatin, simvastatin acid plasma concentration
- Secondary Outcome Measures
Name Time Method simvastatin, simvastatin acid pharmacokinetic parameters (AUC, Cmax, T1/2, etc)