Analysis of pathogenic role of soluble immune semaphorin in autoimmune diseases.
Not Applicable
- Conditions
- autoimmune diseases (including rheumatoid arthritis and osteoarticular diseases (including osteoarthritis and osteoporosis)
- Registration Number
- JPRN-UMIN000013076
- Lead Sponsor
- Osaka University Graduate School of Medicine
- Brief Summary
evels of sSema4D were elevated in RA patients, and disease activities were correlated with serum levels of sSema4D. Treatment with an anti-Sema4D antibody suppressed arthritis in CIA. Levels of sSema4D were elevated in ANCA associated vasculitis patients. Neutrophil surface Sema4D functions as a negative regulator of neutrophil activation. Proteolytic cleavage of Sema4D as observed in patients with AAV may amplify neutrophil-mediated inflammatory responses.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
-complicated with active infectious diseases -The patients who the doctors in charge consider should not enter this study.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method