New Biomarkers in Axial Sypondyloarthropathy; SII and SIRI

Completed

• Conditions: Axial Spondyloarthritis
• Interventions: Other: lab testing

• Registration Number: NCT05914532
• Lead Sponsor: Istanbul Training and Research Hospital

Brief Summary

investigators aimed to evaluate the relationship between Systemic Immune Inflammation Index (SII) and Systemic Inflammation Response Index (SIRI) and disease activity in patients with axial spondyloarthropathy (SpA).

Detailed Description

The clinical characteristics and laboratory data of the patients and healthy controls participating in our study were obtained through the hospital system. Then, the new biomarkers SIRI and SII values were calculated. SIRI= neutrophil count\*monocyte count/lymphocyte count and SII= neutrophil count\*platelet count/lymphocyte count. Then, SIRI and SII values were compared between groups. The relationship between disease activity and SIRI and SII values in the patient group was examined.

Study Timeline

• Study First Submitted: 2023-06-10
• Study First Submitted QC: 2023-06-21
• Study Start: 2023-06-22
• Study First Posted: 2023-06-22
• Primary Completion: 2023-07-10
• Status Verified: 2023-08
• Study Completion: 2023-08-10
• Last Update Submitted: 2023-08-21
• Last Update Posted: 2023-08-23

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 155

Inclusion Criteria

• SpA patients diagnosed according to the 2009 Assessment of Spondyloarthritis International Society classification criteria
• 51 healthy controls working in our hospital,

Exclusion Criteria

infections, coronary artery disease, kidney and liver dysfunction, cancer diagnosis, surgery in the last three months, diabetes mellitus diagnosis, hypertension and pregnant women

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
group 2	lab testing	axial spondyloarthropathy
group 1	lab testing	healthy controls

Primary Outcome Measures

Name	Time	Method
Comparison of SIRI and SII between Patient and Healthy Control	Baseline	SIRI= neutrophil count\*monocyte count/lymphocyte count and SII= neutrophil count\*platelet count/lymphocyte count.

Secondary Outcome Measures

Name	Time	Method
Correlation analysis of SIRI and SII with scales and laboratory findings	Baseline	SIRI= neutrophil count\*monocyte count/lymphocyte count and SII= neutrophil count\*platelet count/lymphocyte count.

Trial Locations

Locations (1)

Istanbul Training and Resarch Hospital; 🇹🇷 Istanbul, Turkey