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临床试验/NCT02434185
NCT02434185已完成不适用

The Bilateral Deficit Phenomenon, Functional and Dynamometric Assessment in Postmenopausal Women

Universidad Católica San Antonio de Murcia1 个研究点 分布在 1 个国家目标入组 20 人开始时间: 2015年3月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
发起方
入组人数
20
试验地点
1
主要终点
Assess the maximum force of lower limbs during bilateral and unilateral contraction

研究概览

简要总结

The bilateral deficit phenomenon (BLD) is defined as an inability of the neuromuscular system to generate maximal force when two homonymous limb operate simultaneously (bilateral contraction) with respect to the force developed when both limbs acts separately (unilateral contraction). From an applied perspective, movement patterns of bilateral homonymous limb are often developed during activities of day living, e.g. rising from a chair or opening a jar. The BLD can be considered an intrinsic property of the human neuromuscular system but could be enough important to constitute a performance-limiting factor for postmenopausal women that involves a degenerative loss of muscular strength. Therefore, a specific analysis of this phenomenon and its relation with activities of daily living, such as climbing a step and rising from a chair, is crucial for detecting variables of neuromuscular performance and develop strategies to minimize the loss of strength.

详细描述

  • 20 postmenopausal women unexperience in strength training or resistance training, without musculoskeletal, neurological diseases, and cardiovascular limiting-diseases were recruited.
  • Maximum strength of lower limbs during leg-press exercise was measured for future analysis.
  • The force-time curves were measured during climbing a step and rising from a chair.
  • A fragility phenotype test was applied to the subjects to determine frailty phenotype classification, including; weight loss of greater than 10 lbs in the past 12 months, maximal handgrip strength, time to walk 15-ft at usual pace, self-reported leisure time physical activity, and self-reported exhaustion.
  • The anthropometric measurements were performed by dual energy X-ray absorptiometry.

研究设计

研究类型
Observational
观察模型
Other
时间视角
Cross Sectional

入排标准

年龄范围
50 Years 至 70 Years(Adult, Older Adult)
性别
Female
接受健康志愿者

入选标准

  • Postmenopausal women

排除标准

  • Unexperienced in strength training or resistance training.
  • Not musculoskeletal diseases.
  • Not neurological diseases.
  • Not cardiovascular limiting-diseases.
  • Not fragility or pre-fragility phenotype.

结局指标

主要结局

Assess the maximum force of lower limbs during bilateral and unilateral contraction

时间窗: Screening visit

Assess the force-time curve during climbing a step

时间窗: Screening visit

Assess the force-time curve during climbing rising from a chair

时间窗: Screening visit

Assess bone mineral-free lean tissue mass by dual energy X-ray absorptiometry

时间窗: Screening visit

Assess the fragility phenotype of the subjects

时间窗: Screening visit

Assess the rate of force developed in time intervals (0-50, 50-100, 100-150ms) of lower limbs during bilateral and unilateral contraction

时间窗: Screening visit

Assess fat-tissue mass and lean-tissue mass composition

时间窗: Screening visit

次要结局

未报告次要终点

研究者

发起方
Universidad Católica San Antonio de Murcia
申办方类型
Other
责任方
Principal Investigator
主要研究者

Juan Diego Ruiz-Cárdenas

BSc, MSc

Universidad Católica San Antonio de Murcia

研究点 (1)

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