Assessment of Bilateral Deficit Phenomenon During Dynamic Plantar Flexion Task in Patients With Haemophilic Arthropathy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 17
- 试验地点
- 1
- 主要终点
- Assessment of Bilateral Index of Rate of Development During the Preparation Phase
研究概览
简要总结
Trial to assess the bilateral deficit phenomenon during dynamic plantar flexion task in patients with haemophilic arthropathy Describe the differences in terms of the physical variables (muscular strength, range of motion and proprioception) in patients with hemophilia who have conducted a home treatment with a digital tool.
Bookmark the relationship between clinical history of joint bleeds and clinical manifestations in standing and walking.
详细描述
- Assess the bilateral deficit phenomenon during dynamic plantar flexion task in patients with haemophilic arthropathy.
- Indicate the independent variables that influence the development of strength and contractile activity, with or without previous joint bleeds in haemophilia patients with minors.
- Observe the descriptive variables people influence the standing, the incorporation from sitting and jumping.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 50 Years（Adult）
- 性别
- Male
- 接受健康志愿者
- 否
入选标准
- •Patients diagnosed with hemophilia A and B.
- •With or without joint involvement clinically diagnosed, and with or without a previous history of hemarthrosis joint load legs.
- •In prophylactic regimen with FVIII / FIX concentrates .
- •Residents in the Autonomous Community of the Region of Murcia.
排除标准
- •Patients without walking ability.
- •Patients diagnosed with other congenital coagulopathy (von Willebrand disease, etc..).
- •Patients with neurological or cognitive impairments that prevent understanding the questionnaires and physical tests.
- •Patients whose parents or guardians have not signed the informed consent document.
结局指标
主要结局
Assessment of Bilateral Index of Rate of Development During the Preparation Phase
时间窗: Screening visit
Assessment of Bilateral index of rate of development during the preparation phase with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA)
Assessment of Rate of Development During the Preparation Phase
时间窗: Screening visit
Assessment of rate of development during the preparation phase with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA)
Assessment of Bilateral Index of Maximal Peak Force
时间窗: Screening visit
Assessment of bilateral index of maximal peak force with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA).
Assessment of Bilateral Index of Rate of Development During the Acceleration Phase
时间窗: Screening visit
Assessment of bilateral index of rate of development during the acceleration phase with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA)
Assessment of Maximal Velocity of Movement
时间窗: Screening visit
Assessment of maximal velocity of movement with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA)
Assessment of Maximal Peak Force
时间窗: Screening visit
Assessment of maximal peak force with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA)
Change of Joint Condition Based on Clinical Assessment
时间窗: Screening visit
Spanish version of the Haemophilia Joint Health Score 2.1 (HJHS). Additive scale that assesses from 0 to 24 points joint status of patients with haemophilia (0: no joint damage; 24: maximum joint damage). The variables studied in this scale are: Swelling (range 0-3); Duration of swelling (range 0-1); Muscle atrophy (range 0-2); Crepitant in motion (range 0-2); Loss of Flexion (range 0-3); Loss of extension (range 0-3); Joint pain (range 0-2): Strength (range 0-4); Gait (range 0-4)
Assessment of Rate of Development During the Acceleration Phase
时间窗: Screening visit
Assessment of rate of development during the acceleration phase with a force platform (Kistler 9286 BA model, Kistler Instruments, Amherst, NY, USA)
次要结局
- Joint Bleeding Before the Assessment(Screening visit)
- Weight of the Patients With Haemophilia(Screening visit)
- Diagnosis, Severity of Hemophilia, Treatment (Prophylactic or on Demand)(Screening visit)
- Height of the Patients With Haemophilia(Screening visit)
- Body Mass Index of Patients With Haemophilia(Screening visit)
- Age of Patients With Haemophilia(Screening visit)
研究者
Rubén Cuesta-Barriuso, PhD
PhD
Universidad Católica San Antonio de Murcia