Feasibility of ultrasound particle image velocimetry to quantify flow in the abdominal aorta before and after endovascular aneurysm repair

Completed

Conditions: Abdominal aortic aneurysm
enlargement of the large blood vessel
10002363

Registration Number: NL-OMON52210

Lead Sponsor: Rijnstate Ziekenhuis

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 12

Inclusion Criteria

- Male or female > 18 years of age
- BMI * 30 kg/m2
- Infrarenal AAA
- Scheduled for elective EVAR
- Informed consent form understood and signed, and agrees to all visits

Exclusion Criteria

- Hypersensitivity to the active substance(s) or any of the excipients in
Sonovue
- Right-to-left cardiac shunt
- Severe pulmonary hypertension (pulmonary artery pressure > 90mmHg)
- Uncontrolled systemic hypertension
- Severe pulmonary disease (e.g. COPD GOLD 3 or 4, adult respiratory distress
syndrome)
- Clinically unstable cardiac disease (recent, < 3 months, or ongoing
myocardial infarction, unstable angina at rest, recent percutaneous coronary
intervention, clinically worsening cardiac symptoms, severe cardiac
arrhythmia*s, endocarditis, etc.)
- Prosthetic valves
- Loss of renal function (GFR < 31 ml/min), end-stage renal disease
- End-stage liver disease
- Sepsis
- Hypercoagulable status, recent (< 3 months) thrombosis
- Congestive heart failure (class III or IV)
- Pregnancy
- MRI exclusion criteria (pacemakers, cerebral vascular clips, claustrophobia)
- Heavily calcified aortoiliac arteries (based on the preoperative CT
angiography scan)

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Vector velocity data derived from the echoPIV analysis will be used to<br /><br>calculate and visualize the spatiotemporal blood flow velocity profiles. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Vector velocity data derived from the PC MRI scan will be used to calculate<br /><br>and visualize the spatiotemporal blood flow velocity profiles and to validate<br /><br>the echoPIV results.<br /><br>- Pre- and postoperative spatiotemporal velocity profiles obtained with echoPIV<br /><br>will be compared to evaluate the influence of the placement of a stent graft on<br /><br>local hemodynamics.<br /><br>- From both datasets blood flow derived parameters, such as vector complexity<br /><br>and vorticity, will be calculated. Moreover, specific blood flow patterns like<br /><br>recirculations or blood stasis will be evaluated thoroughly. </p><br>