ltrafast ultrasonic COMpound Push wave imAging and Strain eStimation (Ultra-COMPASS) for individual plaque stratification in the carotid arteries

Completed

Conditions: arteriosclerosis carotid arteries
10003216

Registration Number: NL-OMON51016

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 0

Inclusion Criteria

- Ischemic stroke or transient ischemic attack in anterior flow area
- Opportunity to undergo Ultra-COMPASS ultrasound measurements *7 days after
initiation of first clinical symptoms
- Stenosis 30-70% of carotid arteries based on clinically performed carotid
ultrasound or thickening of at least 2mm on CT/MR scan
- *18 jaar
- Informed consent

Exclusion Criteria

- Total occlusion common carotid artery or internal carotid artery
- Cardio-embolic nature of ischemic stroke (a.o. atrial fibrilation, valvular
prothesis, endocarditis, recent myocardial infarction)
- Restenosis after carotid endarterectomy
- Acute myocardial infarction
- Radiotherapy-induced carotid stenosis

Study & Design

Study Type: Observational non invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Change in plaque composition (= change in plaque stiffness) measured with<br /><br>Ultra-COMPASS measurements </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>- Determine the association between (changes in) Ultra-COMPASS measurements and<br /><br>the lipid-lowering drugs used 6 and 12 weeks after ischemic stroke.<br /><br>- Determine the association between Ultra-COMPASS measurements and recurrent<br /><br>cardiovascular events (TIA / cerebral infarction / myocardial infarction/death)<br /><br>6 and 12 weeks after ischemic stroke.<br /><br>- Determine the association between Ultra-COMPASS measurements and (changes in)<br /><br>low-density lipoprotein levels 6 and 12 weeks after ischemic stroke (if known). </p><br>