Ultrasound Imaging and Quantitative Vibro-Acoustic Assessment of Rickets Under the Age of Ten
- Conditions
- Rickets
- Registration Number
- NCT06385938
- Lead Sponsor
- Mayo Clinic
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- Not specified
Inclusion Criteria:<br><br> - Cases: Prepubertal children less than 10 years of age with active nutritional or<br> genetic rickets at enrollment (RSS>1.5 based on radiographs of the wrists and knees<br> performed within 3 months prior to enrollment). Cases will be recruited from the<br> Pediatric Endocrinology Bone Clinic or from the Mayo Clinic outpatient or inpatient<br> services in Rochester, MN. Cases who return for follow-up and demonstrate<br> improvement in RSS=1.0 will be eligible for a single repeat ultrasound evaluation.<br><br> - Controls: Healthy children empaneled in Mayo Clinic primary care (Family Medicine or<br> Community Pediatrics) matched for age (±3 months), sex, and BMI (±0.5 kg/m2)<br><br>Exclusion Criteria:<br><br> - Known fracture at imaging site<br><br> - Rickets of prematurity
Not provided
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Relationship of quantitative vibro-acoustic ultrasound and rickets severity score
- Secondary Outcome Measures
Name Time Method Relationship of ultrasound images with radiographic evidence of rickets;Case-control comparison of quantitative vibro-acoustic ultrasound measurements between children with rickets and control subjects;Longitudinal changes in vibro-acoustic ultrasound measurements with treatment of rickets