Non-invasive Evaluation of Coronary Pathology by Transthoracic Doppler Echocardiography. A Comparative Study to Coronary Angiography.
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Stable Angina Pectoris
- Sponsor
- Norwegian University of Science and Technology
- Enrollment
- 110
- Locations
- 1
- Primary Endpoint
- pr patient evaluation
- Status
- Completed
- Last Updated
- 9 years ago
Overview
Brief Summary
Non-invasive evaluation of patients with stable angina and unstable coronary syndromes with transthoracic Doppler echocardiography to evaluate presence of significant coronary stenoses. Blinded evaluation and comparison with coronary angiography: presence and location of stenoses, and head to head comparison of clinical value and patient classification.
Detailed Description
Transthoracic Doppler echocardiographic evaluation with extensive evaluation of coronary stenoses in all 3 main branches using colour flow, pulsed Doppler and Coronary flow velocity reserve (CFVR)after pharmacologic stress with adenosin in the area of LAD and RDP. Blinded evaluation of Doppler results and coronary angiography regarding the other examination modality. Coronary angiography diagnostic "gold standard". Only stable and unstable patients otherwise scheduled for angiography on clinical reasons will be examined and included in the study. Added January 2007 after ethics committee approval: comparison of CFVR with invasive fractional flow reserve (FFR) in selected subset of patients.
Investigators
Eligibility Criteria
Inclusion Criteria
- •unstable angina or acute myocardial infarction, or stable angina pectoris and
- •scheduled for coronary angiography on accepted clinical reasons
Exclusion Criteria
- •past coronary artery grafting
Outcomes
Primary Outcomes
pr patient evaluation
Time Frame: Inhospital
Diagnostic yield: Accuracy, positive and negative predictive value.
Time Frame: Inhospital
Secondary Outcomes
- pr stenosis evaluation(Inhospital)