Description of Insulin Resistance in Patients With Chronic Heart Failure

Completed

• Conditions: Chronic Heart Failure

• Registration Number: NCT02013739
• Lead Sponsor: Hasselt University

Brief Summary

The purpose of this study is to describe insulin resistance in a general chronic heart failure population, in combination with muscle strength, body composition and cardiac function.

It is assumed that insulin resistance is increased in CHF patient, and that this is related to decreased muscle strength and decreased lean tissue mass.

Detailed Description

Not available

Study Timeline

• Study Start: 2011-05
• Primary Completion: 2012-12
• Status Verified: 2013-12
• Study Completion: 2013-12
• Study First Submitted: 2013-12-08
• Study First Submitted QC: 2013-12-11
• Last Update Submitted: 2013-12-11
• Study First Posted: 2013-12-17
• Last Update Posted: 2013-12-17

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 80

Inclusion Criteria

• diagnosis of chronic heart failure for at least 6 months,
• clinically stable (not hospitalized) for more than 3 months prior to the onset of the study,

Exclusion Criteria

• glucose lowering medical therapy

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Glucose tolerance	day1	glucose and insulin concentration measurements in blood during oral glucose tolerance test

Secondary Outcome Measures

Name	Time	Method
HbA1c, blood lipids, BNP	day 1
Muscle strength: maximal strength tested on a isokinetic dynamometer	Day 1
Body composition: dual energy x-ray absorptiometry	Day 1
cardiac function: echocardiography, retrospective from hospital files	retrospective
Health-related quality of life: MLHFQ and Eq5d	Day 1

Trial Locations

Locations (1)

Hasselt University; 🇧🇪 Hasselt, Limburg, Belgium