Skip to main content
MedPathMedPath Home
Clinical Trials/ISRCTN35898459
ISRCTN35898459
Completed
Phase 4

Randomised controlled trial of treatments for pyoderma gangrensoum

ottingham University Hospitals NHS Trust (UK)0 sites140 target enrollmentMay 26, 2009
Share to TwitterShare to FacebookShare to LinkedInShare to Reddit
ConditionsPyoderma gangrenosum (PG)Skin and Connective Tissue DiseasesPyoderma gangrenosum

Overview

Phase
Phase 4
Intervention
Not specified
Conditions
Pyoderma gangrenosum (PG)
Sponsor
ottingham University Hospitals NHS Trust (UK)
Enrollment
140
Status
Completed
Last Updated
9 years ago
OverviewInvestigatorsEligibility CriteriaOutcomesSimilar Trials

Overview

Brief Summary

No summary available.

Registry
who.int
Start Date
May 26, 2009
End Date
TBD
Last Updated
9 years ago
Study Type
Interventional
Sex
All

Investigators

Sponsor
ottingham University Hospitals NHS Trust (UK)

Eligibility Criteria

Inclusion Criteria

  • •1\. PG as diagnosed by the recruiting dermatologist. An ulcerative lesion may have mixed aetiology, but provided the investigator has confidence that a clinical diagnosis of PG is appropriate then they are eligible. Other contributing factors and atypical features will be captured in the case report form.
  • •2\. Must have a measurable ulceration (e.g., not pustular pyoderma gangrenosum)
  • •3\. Age over 18 years, either sex
  • •4\. Able to provide written, informed consent

Exclusion Criteria

  • •Patients cannot participate in either arms of the trial if they have any of the following:
  • •1\. Granulomatous PG \- this condition is very rare and may respond differently to treatment
  • •2\. Concomitant ciclosporin, prednisolone or intravenous immunoglobulin (IVIG) therapy in the previous month
  • •3\. Already participating in another clinical trial
  • •Exclusions for the randomised controlled trial only are as follows:
  • •4\. Pregnant, lactating or at risk of pregnancy
  • •5\. Hypersensitivity to prednisolone or ciclosporin
  • •6\. Biopsy not consistent with PG
  • •7\. Clinically significant renal impairment that would result in the investigator not normally treating with either study drug
  • •8\. Any pre\-treatment investigations, the results of which would prompt the investigator not to use either study drug

Outcomes

Primary Outcomes

Not specified

Similar Trials

Completed
Not Applicable
Group care exercise class vs individual physiotherapy care for the treatment of pelvic and back pain in pregnancyPelvic girdle pain in pregnancyPregnancy and ChildbirthAbdominal and pelvic pain
ISRCTN26238431Cork University Maternity Hospital (Ireland)226
Not yet recruiting
Phase 1
A randomized controlled study for the treatment of depression by regulating circadian rhythm with Sini Sa
ITMCTR1900002301Shaanxi Traditional Chinese Medicine Hospital
Completed
Not Applicable
Treatment of incomplete burst fractures (AO Type A3.1) with dorsal or dorso-ventral proceeding
ISRCTN92182348Centre for Spinal Surgery and Brain Trauma (Zentrum für Wirbelsäulenchirurgie und Neurotraumatologie) Germany60
Not yet recruiting
Phase 2
A Randomised Controlled Trial of Treatment for Post-Concussion Clinical Insomnia in Children and Adolescents: The Effect of Melatonin Plus Sleep Hygiene Education Versus Education AlonePost-Concussion Clinical InsomniaNeurological - Other neurological disordersInjuries and Accidents - Other injuries and accidents
ACTRN12619001585112The Children's Hospital Institute of Sports Medicine120
Completed
Not Applicable
Randomised controlled trial for the treatment of hand arthrosis with prednisolone and naproxe
ISRCTN68990076Vienna Medical University (Austria)246