Circadian rhythm of erythropoietin and melatonin in patients with various degrees of renal insufficiency, Part one

Completed

• Conditions: biological rhythm; circadian processes; 10038430

• Registration Number: NL-OMON31373
• Lead Sponsor: Meander Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 13 May 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 32

Inclusion Criteria

o Patient with various degrees of renal insufficiency, creatinin clearance: minimum 10 ml/min (measured with MDRD), admitted in our hospital
o Informed Consent
o Man/Women between 18 and 85 years
o Understanding and knowledge of the dutch language

Exclusion Criteria

o Instable angina pectoris, heart failure NYHA class IV
o Therapy with erythropoetin, melatonin or/and hypnotics
o Acute renal failure or rapidly progressive glomerulonephritis
o Bleeding or haemolysis as a cause of anaemia
o Deficiency of iron, folate and/or vitamin B12
o Presence of chronic inflammatory disease or clinically significant infection
o Haemoglobinopathies
o Alcohol and/or drug abuse
o Enrolment in another study
o Any kind of disorder that compromises the ability of the subject to give written informed consent and/or to comply with study procedures

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Analysis of the existence of a circadian rhythm in patients with a normal renal<br /><br>function and in patients with variable degrees of renal insufficiency</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>not applicable</p><br>