Single Cell Sequencing Analysis of Thymoma
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 10
- 试验地点
- 1
- 主要终点
- Determination of cell population from thymoma
研究概览
简要总结
The purpose of this study is to understand how genetics play a role in thymoma. Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy. However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may now provide the statistical power to dissect the diverse cellular populations of tumors. This study aims to find out how it affects genetic and protein expression in patients with malignant thymoma, compared to Benign thymoma, at a single-cell level using a flow cytometry and RNA-sequencing protocol.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Patients diagnosed with thymoma
- •Ability to provide written consent and comply with the protocol
- •At least 18 years of age
排除标准
- •Patients undergoing thymoma treatment
- •Patients with previous malignancy
- •Known HIV positive status.
- •Evidence of abnormality of any immune cell population from a drug-induced or genetic cause.
结局指标
主要结局
Determination of cell population from thymoma
时间窗: through study completion, an average of 1 year
The genes expression and the cell population
次要结局
未报告次要终点
研究者
ZHAO An
Principal Investigator
Zhejiang Cancer Hospital