Single Cell Sequencing Analysis of Thymoma

Recruiting

• Conditions: Thymoma
• Interventions: Diagnostic Test: Tissue

• Registration Number: NCT04162691
• Lead Sponsor: Zhejiang Cancer Hospital

Brief Summary

The purpose of this study is to understand how genetics play a role in thymoma. Intratumoral heterogeneity is among the greatest challenges in precision cancer therapy. However, developments in high-throughput single-cell RNA sequencing (scRNA-seq) may now provide the statistical power to dissect the diverse cellular populations of tumors. This study aims to find out how it affects genetic and protein expression in patients with malignant thymoma, compared to Benign thymoma, at a single-cell level using a flow cytometry and RNA-sequencing protocol.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2019-11-06
• Study First Submitted QC: 2019-11-11
• Study First Posted: 2019-11-14
• Study Start: 2020-06-06
• Primary Completion: 2021-06-01
• Status Verified: 2023-01
• Last Update Submitted: 2023-01-12
• Last Update Posted: 2023-01-13
• Study Completion: 2023-12-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

• Patients diagnosed with thymoma
• Ability to provide written consent and comply with the protocol
• At least 18 years of age

Exclusion Criteria

• Patients undergoing thymoma treatment
• Patients with previous malignancy
• Known HIV positive status.
• Evidence of abnormality of any immune cell population from a drug-induced or genetic cause.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Malignant thymoma	Tissue	-
Benign thymoma	Tissue	-

Primary Outcome Measures

Name	Time	Method
Determination of cell population from thymoma	through study completion, an average of 1 year	The genes expression and the cell population

Trial Locations

Locations (1)

An Zhao; 🇨🇳 Hangzhou, China